The purpose of this study is to determine whether spinal anesthesia combined with intrathecal morphine in abdominal hysterectomy on benign gynecological indications gives better outcome concerning duration of hospital stay and postoperative patient comfort than general anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
180
5 mg/mL, 4 mL intrathecally as a single dos
0.4 mg/mL; 0.5 mL intrathecally as a single dosage
2-5 mg/kg body weight/hours IV (intravenously) for sedation during the surgery
Eksjö Hospital
Eksjö, Sweden
Ryhov Hospital
Jönköping, Sweden
University Hospital
Linköping, Sweden
Vrinnevi Hospital
Norrköping, Sweden
Värnamo Hospital
Värnamo, Sweden
Duration of Hospital Stay.
Duration of hospital stay defined as time from start anesthesia to leaving the hospital
Time frame: Within 6 months after surgery
Occurrence and Degree of Postoperative Symptoms.
Time frame: Within 6 months after the surgery
Postoperative Consumption of Analgesics and Antiemetics.
Time frame: Within 6 months after surgery
Complications and Complication Rates.
Time frame: Within 6 months after the surgery
Quality of Life and QALYs (Quality Adjusted Life Years).
Time frame: Within 6 months after the surgery
Sick Leave.
Time frame: Within 6 months after the surgery
The Stress Coping Ability Impact on Postoperative Symptoms and Recovery.
Time frame: Within 6 months after the surgery
Health-related Economy.
Time frame: Within 6 months after the surgery
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Induction of anesthesia with 1-2 mg/kg body weight IV (intravenously). After intubation maintenance dosage of 6-10 mg/kg/hour IV during the surgery
100-200 microgram IV (intravenously) at start of anesthesia. 50-100 microgram IV on demand during surgery.
0.6 mg/kg body weight IV (intravenously) at induction of anesthesia. If additional muscle relaxation is needed during surgery 5-10 mg is injected IV. The drug is given only at induction of anesthesia and during surgery
5 mg is given IV (intravenously) before end of surgery