Plasma B-Type Natriuretic Peptide Concentrations in Preterm Infants < 28 Weeks

Charite University, Berlin, Germany82 enrolled

Overview

The aim of the study was to evaluate BNP in preterm infants \< 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not. We hypothesized that high plasma BNP concentrations on day 2 are associated with the need of PDA intervention in the further course.

From the study infants blood samples (0.1ml) were collected in K-EDTA microtubes within 24 to 48 hours of age through umbilical artery catheter aspiration or routine venous puncture. The samples were spun at 7000 rpm for 3 minutes. Platelet-free plasma was stored at -20°C until BNP analysis of all collected samples was carried out. The BNP assay was performed using a fully automated immunoassay system ADVIA method for the Centaur System (Bayer Diagnostic Division). In preterm infants who were treated with indomethacin or surgical ligation we collected additional blood samples 2-4 hours before intervention and 24 hours after the completion of the ductus treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Infant, Premature Ductus Arteriosus, Patent Natriuretic Peptide Brain

Eligibility

Sex: ALLMin age: 24 HoursMax age: 48 Hours

Medical Language ↔ Plain English

Inclusion Criteria: * Written parental informed consent * Preterm infant \< 28 weeks of gestation * Admitted to our NICU within 48 hours after birth Exclusion Criteria: * No written parental informed consent, * Congenital heart disease, * Death

Locations (1)

Department of Neonatology, Charite Virchow Hospital, Medical University Berlin

Berlin, State of Berlin, Germany

Data from ClinicalTrials.gov

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