Chronic bilateral subthalamic stimulation leads a spectacular clinical improvement in patients with motor complications. However, the post-operative body weight gain involved may limit the benefits of surgery and induce critical metabolic disorder. The aim of this study to determine the energy expenditure in usual conditions of life.
Patients will be studied before (between 3 and 1 months) and after (1 month) STN-DBS surgery. Each time the same measurements will be taken. The principal ones will be : * Clinical examination * Autoevaluation dietary questionnaire * Biological tests * Study in calorimetry chamber (only in Clermont-Ferrand centre) * Heart rate recorded during 7 days in usual conditions of life * Energy expenditure recorded during 14 days in usual conditions of life with normalized water (18O 10 %) and Deuterium oxide (99.94 %D) * Acute Ldopa challenge (in both conditions of dopa and stim) * Apathy evaluation * Body weight, and body compositions measurements
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
34
Patients will be studied before and after STN-DBS surgery
CHU
Clermont-Ferrand, France
heart rate recorded during 7 days in usual conditions of life
Time frame: 7 days in usual conditions of life
energy expenditure recorded during 14 days in usual conditions of life with normalized water (18O 10 %) and Deuterium oxide (99.94 %D)
Time frame: 14 days in usual conditions of life
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