Clinical Assessment of GSK716155 for Type 2 Diabetes Mellitus

Inclusion criteria: * Type 2 diabetes mellitus diagnosed at least 3 months with FPG level \<=240mg/dL and HbA1c between 6.5% and 10% inclusive. * Must be diet controlled - OR - taking a single oral antidiabetic agent (other than thiazolidinediones) and willing to withdraw from this treatment from 2 weeks prior to the study. * Must have a BMI:\<=35kg/m2, 20 to 70 years of age inclusive. * Woman must be of non-childbearing potential. Exclusion criteria: * Positive test result for either syphilis, HBs antigen, HCV antibody, HIV antigen/antibody, or HTLV-1 antibody. * Clinically significant hepatic enzyme elevation. * History of metabolic disease other than T2DM. * Previous use of insulin as a treatment for diabetes within 3 months. * History of severe gastrointestinal disease. * Clinically significant cardiovascular disease. * Significant renal disease as defined by screening lab test. * History of drug (including albumin or albumin containing agents) allergy. * History of alcohol or drug abuse. * Donation of blood in excess of 400mL within previous 4 months. * Previously received any GLP-1 mimetic or any other albumin-containing products.