Safety and Efficacy of Longterm HPN With Two Lipid Emulsions

Inclusion Criteria: * Signed informed consent * Age: 18-80 years * Male and female patients * Patients with a newly indicated need of long-term home parenteral nutrition (HPN) for at least 8 weeks * Patients with an insufficient resorption capacity of the colon that may not be compensated by enteral nutrition * mentally and physically able to adhere to study procedures. * Females agree to apply adequate contraception Exclusion Criteria: * Participation in a clinical study with an investigational drug within one month prior to the start of study * Patients with sepsis, severe sepsis and septic shock * Known or suspected drug abuse * General contra indications for infusion therapy such as acute pulmonary edema, hyperhydration and decompensated cardiac insufficiency * Pregnancy and lactation * Autoimmune disease as e.g. HIV * Known hypersensitivity to egg-, soy-, and fish proteins or any of the ingredients * Hemodynamic failure of any origin (hemorrhagic shock, myocardial infarction, cardiac failure) * Alterations of coagulation (thrombocytes \<150.000 mm3), PT \< 50%, PTT \> 40 sec * Diabetes mellitus with known ketoacidosis within 7 days before onset of study * Renal insufficiency with serum creatinine \> 1.4 mg/dL(\>124 mmol/L) * Patients with severe liver dysfunction with bilirubin \>2.5 mg/dL (\> 43 µmol/L) * Lipid disorders, in particular fasting serum triglycerides \> 250 mg/dL (\>2.86 mmol/L) * necrotizing pancreatitis