Sorafenib in Resected Non-small Cell Lung Carcinoma

Inclusion Criteria: * Patients with histologically confirmed diagnosis of NSCLC pathological stages I, II or III A * Patients must have completely resected disease and may not be treated with prior chemotherapy. Patients must have fully recovered from surgery prior to initiation of study treatment. * Adjuvant radiotherapy for stage III A disease is permitted given that the patient has recovered from all radiation-induced toxicities. In those patients, a complete restaging will be performed prior to enrolment into the trial. * Patients with completely resected NSCLC stage II or III A, who for medical reasons are not eligible for adjuvant chemotherapy consisting of a standard regimen of 4 cycles cisplatin/vinorelbine * Patients with completely resected NSCLC stage II or III A, who are not willing to undergo adjuvant chemotherapy with 4 cycles of cisplatin/ vinorelbine, are also eligible. * Age ≥ 18 years * ECOG performance status ≤ 2 * Normal organ and marrow function defined as: Hematopoetic: absolute neutrophil count \>1,500/mm3, platelet count \> 100,000/mm3, hemoglobin \> 9 g/dL INR \< 1.5 ULN and PTT within normal limits Hepatic: total bilirubin \< 1.5 x ULN, AST or ALT \< 2.5 x ULN Renal: creatinine \< 1.5 x ULN * Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to the start of treatment * Women of childbearing potential and men must agree to use adequate birth contraception prior to study entry and for the duration of study participation. Women and men should use adequate birth control for at least 3 months after the last administration of Sorafenib. * Written informed consent Exclusion Criteria: * Any other histology (e.g. SCLC, carcinoid tumors) or disease stages other than I to III A * Patients who are eligible and willing to undergo a standard adjuvant chemotherapy regimen (4 cycles of cisplatin/vinorelbine) * Any prior systemic anticancer therapy including chemotherapy, targeted agents, experimental therapy or biological therapy for NSCLC * Cardiac disease: congestive heart failure \> class II NYHA, patients must not have unstable angina pectoris or new onset of angina pectoris or myocardial infarction within the past 6 months, or cardiac ventricular arrhythmias requiring antiarrhythmic therapy * Uncontrolled hypertension defined as systolic blood pressure \> 150 mm Hg or diastolic pressure \> 90 mm Hg, despite optimal therapy * Known brain metastasis. Patients with symptoms should undergo CT scan/MRI of the brain to exclude brain metastasis * Active clinically serious infections \> NCI-CTCAE Grade 2 * Thrombotic or embolic events including transient ischemic attacks within the past 6 months * Hemorrhage/bleeding event ≥ NCI-CTCAE Grade 3 within 4 weeks before first dose of study drug * Serious non-healing wound, ulcer or bone fracture * Evidence or history of bleeding diathesis or coagulopathy * Therapeutic anticoagulation with Vitamin K antagonists such as warfarin, phenprocoumon, or with heparins or heparinoids. Low dose warfarin/phenprocoumon is permitted if INR is \< 1.5. Low dose aspirin (300 mg/d) is permitted. * Use of St John's Wort or rifampicin * Major surgery, open biopsy or significant traumatic injury within 4 weeks before first dose of study drug * Known or suspected allergy to Sorafenib or any agent given in the course of this trial * Previous cancer that is distinct in primary site or histology from NSCLC except cervical cancer in situ, treated basal cell carcinoma, superficial bladder tumors or any cancer curatively treated ≥ 3 years prior to study entry. * Substance abuse, medical or psychological condition that may interfere with the patient´s participation in the study