Safety and Tolerability QAT370 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease

Inclusion Criteria: * Patients between 40 and 80 years of age with controlled COPD. * Women must be surgically sterilized or postmenopausal. Additional birth control and post-menopausal information will be available at time of enrollment. * Body mass index (BMI) must be within the range of 18 to 32 kg/m2 Exclusion Criteria: * Participation in any interventional clinical investigation with 4 weeks of study start * Blood loss or donation of 400 mL or more within 2 months of study start Significant illness (other than respiratory) within 2 weeks of study start * Past medical personal or close family history of clinically significant ECG abnormalities * Any medical condition that may interfere with exercise testing or that may make spirometry unsafe * A known hypersensitivity to the drug. * History of immunocompromise, including a positive HIV test result. * History of drug or alcohol abuse within 12 months of study start * Any condition that may compromise patient safety