Rapamycin Versus Mycophenolate Mofetil in Kidney-Pancreas Recipients

Inclusion Criteria: * Patient with Type 1 diabetes and end stage renal disease. * Women of childbearing potential must have had a negative pregnancy test (serum or urine). * Patient agrees to participate in the study and sign an informed consent. * Patient has no known contraindication to the administration of rapamycin or mycophenolate mofetil. * Patient has no history of hypersensitivity to rapamycin or mycophenolate mofetil. Exclusion Criteria: * Patient has history of a malignancy within two years, with the exception of adequately treated localized squamous or basal cell carcinoma of the skin without evidence of recurrence. * Patient is currently abusing drugs or alcohol. * Patient is known or suspected to have an active infection or be seropositive for hepatitis B surface antigen (HBsAg), hepatitis C (HCV) or human immunodeficiency virus (HIV).