Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

Rudolf Foundation Clinic

Overview

The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals. Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

SINGLE

Conditions

Age-Related Macular Degeneration

Interventions

drawing bloodPROCEDURE

Eligibility

Sex: ALLMin age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * man and women over 18 years old * Filled out informed consentBereitschaft zur Teilnahme * Diagnosis of non-exudative/ exudative age related macular dgeneneration Exclusion Criteria: * inherited retinal diseases * other aquired retinal/ macular * missing informed consent

Locations (1)

Rudoulf foundation Clinic

Vienna, State of Vienna, Austria

Outcomes

Primary Outcomes

higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals

Secondary Outcomes

a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD

Data from ClinicalTrials.gov

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