RATIONALE: Giving an infusion of donor lymphocytes may be able to kill cancer cells in patients with hematologic cancer that has come back after a donor stem cell transplant. PURPOSE: This clinical trial is studying how well donor lymphocyte infusion works in treating patients with recurrent or persistent hematologic cancer after donor stem cell transplant.
OBJECTIVES: Primary * Determine if the complete response rate exceeds 10% in patients with recurrent or persistent hematologic malignancies treated with donor lymphocyte infusion. Secondary * Estimate the complete response rate in these patients. * Assess the toxicity of donor lymphocyte infusion in these patients. OUTLINE: Patients receive up to four donor lymphocyte infusions at least 1 month apart in the absence of disease progression, unacceptable toxicity, or uncontrolled graft-versus-host disease.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
39
Given IV
Roswell Park Cancer Institute
Buffalo, New York, United States
Complete Remission Rate
continued or induced complete remission after DLI
Time frame: 100 days post DLI
Duration of Complete Response in Months (Maximum 12)
For participants who achieve a complete remission after DLI, the duration of time until 1) relapse or 2) death in remission or 3) subsequent DLI or 4) last followup (at 1 year after DLI)
Time frame: 1 year post DLI
Acute Graft-versus-host Disease
development of grade III-IV acute graft-versus-host disease (GVHD) per Glucksberg criteria
Time frame: 100 days post DLI
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