The aim of the present study is to investigate and quantify the influence of commonly used anesthetics on auditory and pain evoked potentials.
During surgery patients are exposed to different auditory and sensory stimuli. In this study we investigate the influence of different anesthetics to alertness and nociception. In addition to auditory stimuli (AEP as a measure of sedation), Contact Heat Evoked Potential Stimuli (CHEPS), and esophageal evoked potentials from the lower 1/3 of the esophagus are measured to quantify the effects of anesthetics. 60 Volunteers are enrolled into this study. For each drug, three different levels are measured: * level 1 no medication * level 2 low dose of medication * level 3 light sedation dose (volunteer responds to command) Four drugs are measured in the study: propofol, sevoflurane, S-ketamine and remifentanil.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
60
TCI 0.5 mcg/ml 1.0 mcg/ml
continuous infusion 0.05 mcg/kg/min 0.15 mcg/kg/min
continuous infusion 0.25 mg/kg/h 0.50 mg/kg/h
Technische Universität München, Klinikum rechts der Isar, Department of Anesthesiology
Munich, Bavaria, Germany
influence of different drugs on evoked responses
Time frame: 2 hours
discrimination of antinociceptive, visceral-perceptive and sedative effects of anesthetics
Time frame: 2 hours
quantification of anesthetic components of propofol, sevoflurane, S-ketamine and remifentanil
Time frame: 2 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
via face mask 0.40 Vol% 0.80 Vol%