Platelet Inhibition by Aspirin, Acetaminophen and NSAID

Kantonsspital Graubünden11 enrolled

Overview

Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.

An in vivo study on healthy volunteers with combinations of well established drugs

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Hemostasis

Interventions

Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placeboDRUG

1. Acetylsalicylic acid 100mg/po and acetaminophen 3x1g/po for 4 days 2. Acetylsalicylic acid 100mg/po and diclofenac 3x50mg/po for 4 days 3. Acetylsalicylic acid 100mg/po and naproxen 3x250mg/po for 4 days 4. Acetylsalicylic acid 100mg/po and placebo 3x1/po for 4 days

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers Exclusion Criteria: * Administration of drugs affecting platelets * History of bleeding * Gastrointestinal disorders * Hypersensitivity to aspirin and/or NSAID * Pregnancy and breast feeding

Locations (1)

Kantonsspital Graubünden, Department of Internal Medicine

Chur, Switzerland

Outcomes

Primary Outcomes

platelet aggregation

Time frame: 5 days

Data from ClinicalTrials.gov

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