A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)

Inclusion Criteria: * age \> 49 years * chronic knee discomfort based on the affirmative response to the question "During the past 6 months, have you had any pain in the knee more than half the days of the month ?" * WOMAC pain subscale score ≥ 1 * tibiofemoral or patellofemoral osteoarthritis on anteroposterior weight-bearing semi-flexed or lateral knee radiographs with at least one osteophyte and no significant joint-space-narrowing * clinical examination confirming knee pain or discomfort referable to the knee joint * prepared to refrain from use of glucosamine, chondroitin, sAME and doxycycline * stable medication and/or supplement use Exclusion Criteria: * use of glucosamine, chondroitin, diacerein or doxycycline within 14 weeks prior to randomization * serious medical conditions or impairments that, in the view of the investigator, would obstruct their participation in the trial * individuals who are expected not to comply with the study protocol * plan to permanently relocate from the region during the trial period * planned knee arthroplasty in the study knee * active pathology of confounding origin which may cause pain, extending to the knee * pregnancy * any contra-indication to having an MRI scan