To compare localiezd radiotherapy to localized radiotherapy followed by 6 cycles of chemotherapy in the treatment of localiezd low grade lymphoma
The standard treatment ol localized low grade lymphomas is Radiotherapy alone can offer long term remissions to some patients . No study have clearly demonstrated the interest of chemotherapy. The purpose of the study is to determine wether prednisone administrated after first line local radiotherapy (30 GY) can pre in the treatment of localized low grade lymphomas of adult patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
132
mini chep+ radiotherapy
chemotherapy minichep 6 courses
Regional university hospital
Besançon, France
failure free survival at 5 years
Time frame: 5 years
overall survival at 5 years
Time frame: 5 years
response rates at the end of the treatment
Time frame: 6 months
prognstic value of molecular analyses in blood and marrow
Time frame: 6 months
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