Study to Assess the Pharmacokinetics and Pharmacodynamics of GSK461364 in Subjects With Non-Hodgkins Lymphoma

Inclusion Criteria: * Confirmed diagnosis of advanced solid tumor or Non-Hodgkins Lymphoma (excluding HIV-associated lymphoma) that has relapsed or is refractory to standard therapies * At least 18 years of age * Female who are of non-childbearing potential or who have a negative pregnancy test who uses approved contraception * Male with a female partner of childbearing potential must have had a vasectomy or both are using approved contraception * Lab values that are within range as described in the protocol * Paraffin-embedded archival tumor tissue available for testing * Signed written informed consent Exclusion Criteria: * Undergone major surgery or received anti-cancer therapy * History of hemolytic anemia * Clinical lab tests that are out of range as described in the protocol * Females who are pregnant or lactating * Significant heart problems * Serious or unstable pre-existing medical or psychiatric condition * Are not able to comply with the study protocol * Use of prohibited medications * Have low blood pressure * Evidence of symptomatic or untreated central nervous system involvement and require corticosteroids or anti-epileptic meds