A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation

Inclusion criteria: * Body weight \>50kg * Body Mass Index (BMI): 19-30 * Healthy men with long term (at least 6 months) symptoms of PE * Erectile Dysfunction - (patients should have EF(Erectile Function) domain of IIEF(International Index of Erectile Function questionnaire \>26 or normal) * No history of reduced sexual desire * No history of significant psychiatric illness or currently active significant medical illness * No SSRI's(Selective Serotonin Reuptake Inhibitors) use within the last 4 months * No history of diabetes, renal or hepatic disease * No significant injuries to the head or spinal cord i.e. history of head injury, spinal cord injuries, and conditions such as multiple sclerosis. Exclusion criteria: * Previous or current use of any PDE-5(Phosphodiesterase type 5) inhibitors for the treatment of Erectile Dysfunction * Subject receiving treatment in the last 6 months for depression, psychiatric disorders, mood disorders, schizophrenia, substance abuse or anxiety disorders * Subject is taking tricyclic anti-depressants, selective serotonin reuptake inhibitors (or related drugs), mono-amine oxidase inhibitors or ß-blockers * Subject has received or is continuing to receive any treatment for PE (e.g. local anaesthetic spray, or intra-cavernosal injection) in the four weeks prior to the study start * Subject has a history of other clinically significant organic diseases e.g. uncontrolled hypertension, ischemic heart