This pilot study will compare the effect of diffusive versus convective Continuous Renal Replacement Therapy (CRRT) in children with sepsis who require CRRT. The hypothesis for the study is that convective forms of CRRT provide enhanced clearance of cytokines and improved clinical responses as compared to a diffusive CRRT modality.
The purpose of this study is to test the hypothesis that convective forms of Continuous Renal Replacement Therapy (CRRT) provides enhanced clearance of cytokines compared to a diffusive CRRT modality. Also, we plan to test the hypothesis that patients who receive convective CRRT modalities demonstrate improved clinical responses to patients who receive a diffusive CRRT modality.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Patients will be randomized to either arm for the first 24 hours of the study and then crossover to the second arm for the second 24 hours of the study.
Children's National Medical Center
Washington D.C., District of Columbia, United States
All Children's Hospital
St. Petersburg, Florida, United States
Children's Healthcare of Atlanta
Atlanta, Georgia, United States
Helen De Vos Children's Hospital
Grand Rapids, Michigan, United States
A 25% additional decrease in IL-6 concentration change
Time frame: The First 24 hours of CRRT
Other cytokine removal rates
Time frame: First 24 hours of CRRT
Cytokine absorption on the CRRT membrane
Time frame: First 24 hours of CRRT
Hemodynamic parameters
Time frame: First 24 hours of CRRT
Changes in serum cytokine concentrations and clearance
Time frame: After crossover, from 24-48 hours
Changes in serum cytokine concentrations
Time frame: From beginning to end of the study, independent of modality
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Texas Childrens Hospital
Houston, Texas, United States