Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week

Inclusion Criteria: * 85ys\>age\>14ys * APACHE II\<25 * Lung infiltrates together with at least one of the following symptoms:cough, sputum, dyspnea with or without fever * smear or culture positive for candida spp. from sputum Exclusion Criteria: * Pregnancy * Hypersensitivity to fluconazole * Isolated candida was non-sensitive to fluconazole * Severe liver or renal diseases who can not tolerate fluconazole treatment * With at least one of the following high risk factors:organ transplantation, neutropenia\>10ds, long term glucocorticoids therapy(equal to prednisone 30mg/d longer than 2 weeks), immunosuppressive therapy within 30ds, AIDS * With one of the microbiological evidence:isolation of candida spp. from blood or other kinds of sterile site(not including urine), filamentous fungi isolated from sputum or BALF, cryptococcus isolated from sputum or CSF, galactomannan antigen positive twice for blood * Probable or possible pulmonary aspergillosis * Definite oral or esophageal candidiasis