Phase I Multiple-Ascending Dose (Japan)

Inclusion Criteria: * Japanese male and female subjects * Ages 20 to 70 years old * Established diagnosis of T2DM * BMI \< 32 kg/m2 * Fasting glucose ≤ 240 mg/dL, while on antidiabetic diet alone * HbA1C 6.0 - 10.0% Exclusion Criteria: * Symptomatic T2DM defined as polyuria and/or polydipsia within 2 months of enrollment * History of diabetic ketoacidosis or hyperosmolar nonketotic syndrome * History of incontinence or bladder dysfunction including nocturia