Benefit of Immunoprophylaxis on Fibrosis to Reduce Viral Load After Liver Transplantation

Inclusion Criteria: * patients who received a first liver transplantation, * presenting with a qualitative or quantitative PCR positive for hepatitis C virus at time of transplantation, whatever the transaminase activity, * Women of childbearing potential with a negative pregnancy test, * Male or female patients who agree to use an effective method of contraception, * patients who signed a written informed consent form to participate in the study, * patients who are compliant and likely to follow the visits specified by the study protocol Exclusion Criteria: * • Preoperative serious renal impairment (serum creatinine levels \> 200 µmol/l), * repeat transplantation, * multiple organ transplantation, * transplantation performed with an organ transplant obtained from a living donor or a reduced or shared organ grafts, * serious concomitant disorder, * positive serology for HBs antigen or HIV positive at time of enrollment, * previous history of nonhepatic cancer (except for localized skin cancer), * presence of a hepatocellular carcinoma, for which the primary lesion exceeds 5 cm or is complicated by portal thrombosis or metastatic disease, * an investigational product or therapy administered less than one month before entry into the study.