The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages
Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases. We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years. The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.
Study Type
INTERVENTIONAL
Purpose
PREVENTION
Masking
NONE
Enrollment
32
2-minute Bondet test
University Hospital of Zurich
Zurich, Switzerland
Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress
Time frame: 60 minutes
Evaluation of the plasma level of endothelin, catecholamines and salivary cortisol level before and after mental stress
Time frame: 60 minutes
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