Phase I Epigenetic Priming Using Decitabine With Induction Chemotherapy in AML

Inclusion Criteria: * Patients must have histologically or cytologically confirmed diagnosis of Acute Myelogenous Leukemia (AML) * Patient is \>18 and ≤ 60 years of age. * AML subgroup is associated with less-than-favorable risk as defined by: * The absence of good risk molecular features: t(8;21), inv(16), t(16;16), or t(15;17) translocations identified by FISH or standard metaphase karyotyping or evidence for the corresponding fusion transcripts, AML1-ETO, CBFβ-SMMHC, or PML-RARα, as identified by RT-PCR or suggested by the FAB M3 phenotype; * A history of an antecedent myelodysplastic syndrome; * A history of an antecedent Philadelphia-chromosome negative myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, primary myelofibrosis); * Treatment-related AML believed secondary to prior cytotoxic chemotherapy for an unrelated disease. * Patient has adequate cardiac function as defined by: * An echocardiogram or MUGA scan demonstrating an ejection fraction within normal limits. * ECOG performance status \> = 2. * Patient has adequate hepatic/renal function as defined by: * Total bilirubin ≤ 2 mg/dL. Patients with documented evidence of Gilbert's Syndrome resulting in elevated total bilirubin levels will be eligible, provided all other eligibility criteria are met. * Aspartate transaminase (AST) and alanine transaminase (ALT) ≤1.5 x the ULN. * Creatinine ≤ 2 mg/dL (or a creatinine clearance \>50 mL/min/1.73 m2, by direct measure). * Patient is not childbearing: * Female subjects must be surgically sterile, postmenopausal, or have a β-HCG indicating that they are not pregnant at the time screening is performed. * Female patients of childbearing potential must agree to take appropriate measures to ensure that they do not become pregnant while enrolled on protocol (i.e., within 2 months of administration of chemotherapy). * Male patients must agree to take appropriate measures to ensure that they do not father a child while enrolled on protocol (i.e., within 2 months following administration of chemotherapy). * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * AML with "good risk" molecular features: karyotype demonstrating the presence of t(8;21), inv(16), t(16;16), or t(15;17) translocations identified by FISH or standard metaphase karyotyping or evidence for the corresponding fusion transcripts, AML1-ETO, CBFβ-SMMHC, or PML-RARα, as identified by RT-PCR or suggested by the FAB M3 phenotype. * Patient has a history of chronic myelogenous leukemia or has molecular evidence of the t(9;22) translocation by FISH, metaphase karyotype or RT-PCR for the BCR-ABL fusion transcript. * Patient has received chemotherapy (other than hydroxyurea) or radiation within the 2 weeks prior to planned therapy on this study. * Patient has an active second malignancy. * Patient has a medical condition or illness considered by the Investigator to constitute an unwarranted high risk for investigational drug treatment. * Patient has an uncontrolled serious infection. * Patient is pregnant or nursing an infant. * Patient has a psychiatric disorder or altered mental status that would preclude understanding of the informed consent process and/or completion of the necessary studies. * Patient has an inability or unwillingness, in the opinion of the Investigator, to comply with the protocol requirements. * Patients with central nervous system (CNS) (or leptomeningeal) involvement by their AML may be considered for treatment at the Investigator's discretion and following discussion with the Medical Monitor, in order to allow for appropriate management. * Patient has circulating blast count \> 50,000/μL (patients may be enrolled if circulating blast count is controlled by hydroxyurea and/or, if clinically indicated, by leukopheresis).