Study of Arixtra (Fondaparinux Sodium) to Prevent Blood Clots in Women Undergoing Abdominopelvic Surgery for Likely Gynecologic Malignancy

Inclusion Criteria: * All patients undergoing open laparotomy (non-laparoscopic) gynecologic surgery. * Patients must be competent to self-administer injections, or must have caregivers or nurses who can perform injections * Patients must have signed an approved informed consent Exclusion Criteria: * Patients with medical history which requires chronic anticoagulation (i.e. previous DVT, pulmonary embolism, atrial fibrillation, heart valve replacement) * Patients with contraindications to anticoagulation (generalized bleeding disorders, peptic ulcer disease, hemorrhagic stroke, etc) * Contraindications to placement of ICDs (history of lower extremity venous stasis ulcers) * Patients receiving low molecular weight heparin or unfractionated heparin for prophylaxis post-operatively * Patients who are unable to receive injections as an outpatient and/or unable to undergo a doppler ultrasound of the lower extremities * Renal insufficiency (creatinine clearance \< 30 mL/min) * Patients who have a body weight \< 50 kg * Hypersensitivity to low molecular weight heparin * Patients who are pregnant or have a positive pregnancy test. * Patients receiving continuous (indwelling) epidural.