RATIONALE: Studying natural killer cells in samples of blood from patients with cancer may help doctors find out how these cells are effected by chemotherapy. PURPOSE: This clinical trial is studying natural killer cells in older patients with acute myeloid leukemia.
OBJECTIVES: Primary * Determine the evolution of functional receptors of natural killer (NK) cells after completion of chemotherapy in elderly patients with acute myeloid leukemia in first remission. Secondary * Measure the kinetics of cytotoxic functional recovery of NK cells. * Determine activation markers of NK cells. OUTLINE: This is a multicenter study. Patients receive 1 course of consolidation therapy comprising an anthracycline and cytarabine to induce first remission. Blood is collected on day 0 of the consolidation course and then every 2 weeks for 8 weeks.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
Marseille, France
Evolution of functional natural killer (NK) cells after chemotherapy
Kinetics of NK cells
Activation markers of NK cells
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