Multiple-Dose, Dose-Escalation Safety, Pharmacodynamics, and Pharmacokinetics Study of Imprime PGG™ Injection

Inclusion Criteria: 1. Be aged 18 to 45 years, inclusive 2. Have a body weight of 45 to 125 kg, inclusive, and a body mass index less than or equal to 30 kg/m2 3. If female, be non-pregnant and non-nursing, and if pre-menopausal, have a negative serum pregnancy test confirmed prior to enrollment and practicing at least two methods of birth control 4. Be healthy as determined by the investigator on the basis of medical history, physical examination, electrocardiogram, and clinical laboratory test results 5. Have the ability to understand the requirements of the study, provide written informed consent, and agree to abide by the study restrictions and to return for the required assessments 6. Have provided written authorization for use and disclosure of protected health information Exclusion Criteria: 1. Have a known hypersensitivity to baker's yeast 2. Have a history of tobacco use within 3 months of first day of screening 3. Be a known or suspected abuser of alcohol or other drugs/substances of abuse at anytime 4. Have an active yeast infection 5. Have a positive hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) test conducted as part of screening 6. Except as otherwise indicated, have taken any prescription medication within 30 days of the last day of screening (Day -1) or over-the-counter medication, herbal preparation, or vitamins within 7 days of the last day of screening (Day -1); the following medications are exempted from this criterion: acetaminophen \[maximum 3 g/day\], female hormone replacement therapy, and oral contraceptives 7. Have participated in an investigational drug study within 30 days or five half lives (whichever is longer) of the last day of screening (Day -1) or have ever participated in a study with Imprime PGG or Betafectin 8. Have donated or lost more than a unit of blood within 30 days of the last day of screening (Day -1) 9. Have any clinical condition that, in the opinion of the principal investigator, warrants exclusion from the study from a scientific, procedural, or safety perspective