12-Week No-Rofecoxib Plus Aspirin Endoscopy Study (0782-003)

Inclusion Criteria: * Has osteoarthritis or rheumatoid arthritis for at least 6 months prior to start of study * Osteoarthritis (OA): must have diagnosis of OA in knee, hip, hand or spine Patient is not on chronic aspirin therapy (taking aspirin at any dose, on a daily basis, for a minimum of 4 weeks prior to Visit 2 for any medical condition * Must be willing to limit alcohol use to no more than 2 drinks per day * Avoid strenuous physical activity Exclusion Criteria: * Mentally or legally incapacitated * Has systemic lupus erythematosus, Paget's disease * Has a history of esophageal, gastric biliary, or small intestine surgery (hiatal surgeries and any GI surgery that causes clinical malabsorption or delayed gastric emptying * Has uncontrolled hypertension * Has uncontrolled diabetes * Has had heart attack, unstable angina, coronary angioplasty, stent placement, coronary artery bypass grafting in the last 6 months * Has congestive heart failure * Has had active liver disease within the last 2 years