Clinical Efficacy of Intravenous Iclaprim Versus Vancomycin in the Treatment of Hospital-Acquired, Ventilator-Associated, or Health-Care-Associated Pneumonia

Inclusion Criteria: * Suspected or confirmed acute bacterial pneumonia due to Gram-positive pathogens in one of the following subgroups: * hospital-acquired pneumonia (HAP), i.e., pneumonia that occurs 48 hours or more after admission, which was not incubating at the time of admission; or * ventilator-associated pneumonia (VAP), i.e., pneumonia that arises more than 48 hours after endotracheal intubation; or * health-care-associated pneumonia (HCAP), i.e., pneumonia diagnosed within 48 hours of hospital admission, in a patient who fulfills at least one of the following criteria: 1. hospitalization for at least two days within 90 days of the current infection, 2. residence in a nursing home or long-term care facility, 3. recipient of intravenous antibiotic therapy, chemotherapy, or wound care within 30 days of the current infection Exclusion Criteria: * Acute Physiology and Chronic Health Enquiry (APACHE) II score \< 8 or ≥ 25. * Pneumonia not requiring empiric or targeted treatment effective against Gram-positive pathogens. * Pulmonary infection due to Gram-positive organisms known to be resistant to either study medication prior to study entry.