Rehabilitation for Patients With Pulmonary Arterial Hypertension

Inclusion Criteria: * All patients must satisfy current diagnostic criteria for pulmonary artery hypertension based on their historical right heart catheter data (within 4 years of study enrollment): Mean PAP \>25mmHg at rest or \>30mmHg with exercise, by a PCWP \<= 15mmHg and by PVR \>3 Wood Units. * Willing and able to participate in 24 bi-weekly rehabilitation sessions, and medical follow-up. * Stable dose of current PAH-specific medication for 3 months prior to enrollment. * New York Heart Association (NYHA) Class II-III. * Women of child-bearing age must demonstrate adequate contraception or undergo a pregnancy test. Exclusion Criteria: * Functional Class NYHA Class I or IV. * PAH due to congenital heart disease, left heart disease, chronic lung diseases (VC or FEV1 \< 60% of predicted) or chronic hypoxia. * Acute intercurrent illness requiring hospital admission in the month proceeding screening. * Any non-PAH medical condition likely to interfere with participation in rehabilitation, e.g. musculoskeletal disorders. * Any uncontrolled or terminal non-PAH medical condition likely to interfere with completion of the study, according to the judgment of the study physician. * Participation in another rehabilitation scheme within 6 months of enrollment in the study. * Current participation in another clinical trial. * Pregnancy or planned pregnancy during the study period.