We wish to compare the effect of long acting vs short acting opioids in chronic non-malignant pain. The study opioid is Dihydrocodeine Continus and Dihydrocodeine 30 mg tablets. We measure pain relief, health related quality of life, sleep, breakthrough pain and depression with validated questionnaires to compare the two treatment arms. Hypothesis: The pain relief will be better and more stable with long acting opioids. Quality of sleep, breakthrough pain and quality of life will also be improved with long acting dihydrocodeine.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
Group 1: 2\* 60 mg dihydrocodeine long acting + up to four placebo short action Group 2: 3\* 60 mg dihydrocodeine long acting + up to six placebo short action Group 3: 4\* 60 mg dihydrocodeine long acting + up to eight placebo short action Group 4: 2 placebo for long acting + up to 4\*30 mg dihydrocodeine short acting Group 5: 3 placebo for long acting + up to 6\*30 mg dihydrocodeine short acting Group 6: 3 placebo for long acting + up to 8\*30 mg dihydrocodeine short acting
National Competency Centre for Complex Disorders
Trondheim, Sør-Trøndelag, Norway
Pain
Validated questionaires which have been properly translated to Norwegian will be used in the assessment of each outcome variable:Pain, Quality and duration of sleep, Quality of life, Depression, Moods and breakthrough pain will be measured.
Time frame: 9 weeks
sleep quality and duration
Validated questionaires which have been properly translated to Norwegian will be used in the assessment of each outcome variable:Pain, Quality and duration of sleep, Quality of life, Depression, Moods and breakthrough pain will be measured.
Time frame: 9 weeks
quality of life
Validated questionaires which have been properly translated to Norwegian will be used in the assessment of each outcome variable:Pain, Quality and duration of sleep, Quality of life, Depression, Moods and breakthrough pain will be measured.
Time frame: 9 weeks
Depression and moods
Validated questionaires which have been properly translated to Norwegian will be used in the assessment of each outcome variable:Pain, Quality and duration of sleep, Quality of life, Depression, Moods and breakthrough pain will be measured
Time frame: 9 weeks
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