Viral-Related Neutrophil Response and Condition Severity in People With ARDS

Inclusion Criteria: * All patients that are eligible for ARDSNet Study 06 (Prospective, Randomized, Multi-center Trial of Aerosolized Albuterol Versus Placebo in Patients with Acute Lung Injury \[ALI\] or Acute Respiratory Distress Syndrome \[ARDS\]) and ARDSNet Study 07 (Prospective, Randomized, Multi-center Trial of Initial Trophic Enteral Feeding Followed by Advancement to Full-Calorie Enteral Feeding vs. Early Advancement to Full-Calorie Enteral Feeding in Patients with Acute Lung Injury \[ALI\] or Acute Respiratory Distress Syndrome \[ARDS\] and Prospective, Randomized, Blinded, Placebo-controlled, Multi-center Trial of Omega-3 Fatty Acid, Gamma-Linolenic Acid, and Anti-Oxidant Supplementation in the Management of Acute Lung Injury \[ALI\] or Acute Respiratory Distress Syndrome \[ARDS\]) will be eligible for co-enrollment in this study * Experiences acute onset of each of the following criteria within a 24-hour time period: 1. Partial pressure of oxygen in arterial blood/fraction of inspired oxygen (PaO2/FiO2) less than or equal to 300; if altitude is greater than 1000 meters, then PaO2/FiO2 must be less than or equal to 300 x (barometric pressure \[PB\]/760) 2. Bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph. The infiltrates may be patchy, diffuse, homogeneous, or asymmetric. 3. Requires positive pressure ventilation via endotracheal tube 4. No clinical evidence of left-sided cardiac failure to account for bilateral pulmonary infiltrates The 48-hour enrollment time window begins when the first three criteria are met. If a patient meets the first three inclusion criteria but has a pulmonary arterial wedge pressure (PAOP) greater than 18 mm Hg, then the first four criteria must persist for more than 12 hours after the PAOP has declined to less than or equal to 18 mm Hg, and still be within the 48-hour enrollment window. Exclusion Criteria: * More than 48 hours since all inclusion criteria were met * Neuromuscular disease that impairs the ability to ventilate without assistance, such as cervical spinal cord injury at level C5 or higher, spinal cord injury, amyotrophic lateral sclerosis, Guillain-Barré syndrome, or myasthenia gravis * Pregnant or breastfeeding * Severe chronic respiratory disease, including chronic hypercapnia (arterial carbon dioxide pressure \[PaCO2\] greater than 45 mm Hg), chronic hypoxemia (PaO2 less than 55 mm Hg or FiO2 = 0.21), hospitalization within the 6 months prior to study entry for respiratory failure (PaCO2 greater than 50 mm Hg and/or PaO2 less than 55 mm Hg on 0.21 FiO2), secondary polycythemia, severe pulmonary hypertension (mean pulmonary arterial pressure \[PAP\] greater than 40 mm Hg), or ventilator dependency * Burns over more than 40% of the total body surface area * Cancer or other irreversible disease or condition for which 6-month mortality is estimated to be greater than 50% * Allogeneic bone marrow transplant within the 5 years prior to study entry * Patient, surrogate, or physician is not committed to full support (exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest) * Severe chronic liver disease (i.e., Child-Pugh score between 11 and 15) * Diffuse alveolar hemorrhage from vasculitis * Morbid obesity (weighs greater than 1 kg/cm) * Unwilling or unable to follow the ARDS network 6 mL/kg predicted body weight (PBW) ventilation protocol * Not expected to survive 24 hours from the time of study entry * No intent to obtain central venous access for monitoring intravascular pressures * Medically unable to receive aerosolized albuterol * Daily use (prior to study hospitalization) of inhaled beta agonist, corticosteroid, or oral leukotriene modifier * Primary physician is unwilling to discontinue inpatient beta agonist use * Acute heart attack or acute coronary syndrome within the 30 days prior to study entry * Severe congestive heart failure * Participation in other experimental medication trial in the 30 days prior to study entry with the exception of the ARDSNet pharmaconutrient nutrition trial (OMEGA) * Heart rate greater than 85% of maximal predicted heart rate (MHR85) as calculated by MHR85 = 85% x (220-age) * Receiving high frequency ventilation