A Randomized Study Evaluating Steroid Hormone Levels, Safety And Tolerability Of GW870086X In Healthy Volunteers

Inclusion criteria: * Healthy male subjects * Liver function tests normal * 18 - 45 years old * Non smoker * Can provide written informed consent * Available to complete the whole trial * Can use the inhalation device correctly * Able to read, understand and write English Exclusion criteria: * Deemed suitable healthy subject * History to sensitivity to the study medication * Any history of breathing problems in adult life * Participated in another trial within 30 days or 5 half-lives of the new chemical entity * Exposed to more than 4 new chemical entities within 12 months * Donated \>500 mL blood within 2 months of screening * Haemoglobin level \< 13g/dl * Use of prescription or non-prescription drugs within 7 days of first dose * Taking drugs that significantly inhibit cytochrome P450 subfamily enzyme CYP3A4 * Drinks more than 4 units a day or 28 units a week * Cannot use DISKHALER device correctly * Positive HepB, HepC within 3 months of screening * Positive HIV test * Positive pre study drug/alcohol screen * Significant cardiac conduction abnormalities * Risk of non-compliance