Increased levels of intracellular calcium are thought to diminish maximal cellular response to insulin and induce insulin resistance. Also, both hypertension and diabetes are thought to be conditions of altered intracellular ionic state. The aim of the present study is to investigate the possible effect of oral calcium supplementation on intracellular ions, insulin sensitivity, 24-h blood pressure and sodium/hydrogen exchanger activity in patients with type 2 diabetes and essential hypertension.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
31
1500 mg of elemental calcium per day.
AHEPA University Hospital
Thessaloniki, Greece
To evaluate the difference in 24h blood pressure measurement and insulin sensitivity between the treatment and the control group.
Time frame: baseline and after 8 weeks of follow up
To evaluate differences in intracellular calcium, magnesium, sodium and potassium concentrations at the end of the follow up period between the calcium supplementation group and the control group.
Time frame: baseline and after 8 weeks of follow up
To evaluate differences in the transmembrane sodium/hydrogen exchanger activity between the active treatment and the control group.
Time frame: baseline and after 8 weeks of follow up
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