Effect of Rosiglitazone on Myocardial Blood Flow Regulation in Type 2 Diabetes

Inclusion Criteria: * Type 2 diabetes * 30-75 years of age * less than 1% fluctuation in HbA1c over 3 months * women must be on contraception * HbA1c 6-9% * willingness to sign approved consent form Exclusion Criteria: * Nursing mothers, pregnant women (excluded by a negative pregnancy test). * Subjects requiring insulin therapy (\>20 units/day) and can not be converted to sulfonylurea therapy without loss of diabetes control. * Patients with a history of drug or alcohol dependence in the last 5 years * Patients with pre-existing cardiovascular disease including coronary artery disease, heart attack, heart failure, abnormal heart rhythms, structural abnormalities and valve disease, peripheral vascular disease and uncontrolled high blood pressure. * Patients with a history of high cholesterol requiring therapy. * Patients with severe systemic disease other than diabetes which has as a recognized complication neuropathy * Patients currently taking drugs which act on the blood vessels (for example for hypertension) * Patients taking antidepressants, or other drugs or medications known to interfere with the uptake or metabolism of catecholamines (stress hormones) * Patients with poor renal function or have significant liver disease * Patients with a history of previous kidney, pancreas or cardiac transplantation. * Patients with a history of "severe hypoglycemia" which required the assistance of a third party or ketoacidosis requiring hospital admission within the last 3 months. * Patients with lung disease for example resulting from chronic obstructive airways disease. * Patients with abnormal thyroid function tests. * Patients having taken other systemic investigational drugs (especially for neuropathy) or initiating a new or experimental insulin delivery device within 3 months of starting the study. * Patients with a history of allergic reactions to multiple drugs or biological products. * Obese patients (BMI greater than 35). * Patients who refuse to sign the informed consent.