Does Ascorbic Acid Reduce Sympathoexcitation in CHF?

Radboud University Medical Center

Overview

In CHF central sympathetic activity is increased. ROS formation seems to play a role in this process. This study analyzes the effect of vitamin C as an antioxidant on central sympathetic activity in CHF

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Conditions

Heart Failure

Interventions

vitamin CDRUG

placeboDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Heart failure of at least New York Heart Association (NYHA) class II * Left ventricular ejection fraction (LVEF) \<= 40% * Age 20-80 years Exclusion Criteria: * Necessity of short-term PCI, CABG or heart transplantation, * Chronic disease of the autonomic nervous system, * diabetes mellitus, * use of tricyclic antidepressant drugs and/or a-adrenergic receptor antagonists.

Locations (1)

Radboud University Nijmegen Medical Centre

Nijmegen, Netherlands

Outcomes

Primary Outcomes

change in central sympathetic output after vitamin C vs. placebo

Data from ClinicalTrials.gov

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