Succinate Salt Version of GSK961081 for Healthy Volunteers

Inclusion Criteria: * Healthy adult males or female aged between 18 and 50 years. * Body mass index within the range 19-29.9 kilograms/metre2 * Forced Expiratory Volume in 1 second (FEV1) \>80% predicted and a FEV1/ Forced Vital Capacity (FVC) ratio \> 0.7 * Subjects are current non-smokers who have not used any tobacco products in the 6-month period preceding the screening visit and have a pack history of \< 10 pack years. Exclusion criteria: * Who have a past or present disease, which as judged by the Investigator and medical monitor may affect the outcome of the study or the safety of the subject * History of respiratory disease * Significant abnormal 12 lead ECG, QTc(B) and QTc(F) value at screening \>450msec on an individual ECG or a PR interval outside the range 120-210 msec * Supine mean heart rate outside the range 40-90 beats per minute (bpm) at screening. * Subject has donated a unit of blood within the 56 days or intends to donate within 56 days after completing the study * Subject is currently taking regular (or course of) medication whether prescribed or not (with the exception of contraceptives, including vitamins and herbal remedies such as St John's Wort. * Subject has participated in a clinical study with a New Chemical Entity (NCE) within the past 3 months * Infected with the Hepatitis B, Hepatitis C, or HIV virus * Subject has a history of drug or other allergy, which, in the opinion of the Investigator, contraindicates their participation