The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement. The function of the endothelium will be tested using ultrasound before and after each treatment. These studies will help us understand why the endothelium is abnormal in patients with coronary artery disease and how L-arginine is acting on endothelial function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
119
Creatine 21 g daily
L-arginine
l-arginine 9 g daily
Brachial artery flow-mediated dilation
Time frame: 5 days
serum arginine, creatine, creatinine, homocysteine
Time frame: 5 days
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