The purpose of this study is to evaluate response to neoadjuvant chemotherapy by imaging and observation of anatomical and biological indicators (i.e. ascites or continuous measurement of tumor marker CA 125). Furthermore the optimal number of preoperative administered cycles of combination chemotherapy with carboplatin and docetaxel should be determined.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
3 cycles of Carboplatin/Docetaxel (3-weekly) preoperative and 3 cycles of Carboplatin/Docetaxel (3-weekly) postoperative
2 cycles of Carboplatin/Docetaxel (3-weekly) preoperative and 4 cycles of Carboplatin/Docetaxel (3-weekly) postoperative
Department of Gynaecolgy and Obstetrics, University hopsital
Bonn, Bonn, Germany
RECRUITINGDepartment of Gynaecology, University hospital
Hamburg, Free and Hanseatic City of Hamburg, Germany
RECRUITINGPreoperative reduction of ascites volume
Time frame: preoperative: after 2nd or 3rd cycle of chemotherapy (3-weekly course)
Evaluation of overall response, Evaluation of postoperative tumor size, Evaluation of perioperative morbidity and mortality, QOL
Time frame: 6 months
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