Immune Response to Influenza Vaccination

The Cleveland Clinic82 enrolled

Overview

The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol. The study will evaluate for a change in response to common antigens over time after influenza vaccination to determine if changes are related to the development of chronic rejection after solid-organ transplantation. We hypothesize that the influenza vaccine contributes to the alloreactivity of T cells verses common HLA types in the donor pool.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Solid Organ Transplantation Chronic Kidney Disease

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Transplant recipients (lung or kidney) 18 years or older, more than 3 months after transplantation * Transplant candidates (kidney) 18 years or older, to recieve influenza vaccination * Healthy volunteers to receive influenza vaccination Exclusion Criteria: * Under 18 years of age * Pregnant * Medical contraindication for vaccine * Transplant recipients receiving acute rejection therapy within one month * Healthy volunteers with autoimmune disease or medications to mediate immune function * Receipt of live, attenuated influenza vaccine, instead of injectable vaccine

Data from ClinicalTrials.gov

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