Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis

University of Wuerzburg62 enrolled

Overview

The purpose of this study is to determine whether patients with Hashimoto thyroiditis and impaired well-being may have a partial secondary adrenocortical insufficiency.

Many patients with Hashimoto thyroiditis who are correctly substituted with thyroid hormones have an impaired well-being. in some people an isolated ACTH deficiency was found. In this study a 1 µg ACTH test is performed to evaluate the adrenocortical function.

Study Type

INTERVENTIONAL

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Hashimoto Disease Adrenal Insufficiency

Interventions

synacthenDRUG

1 µg synacthen in the vein

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written informed consent Exclusion Criteria: * • hypothyroidism of other origin * pregnancy and lactation * oral contraception * glucocorticoid therapy during the last 2 months * History of malignancy or chronic infections (Hepatitis, HIV)

Locations (1)

University of Wuerzburg, Department of Endocrinology

Würzburg, Bavaria, Germany

Outcomes

Primary Outcomes

serum cortisol-peak 30 min after ACTH-stimulation

Time frame: 30 minutes

Secondary Outcomes

serum DHEA-peak 30 min. after ACTH-stimulation,DHEA-S, ACTH

Time frame: 30 minutes

Data from ClinicalTrials.gov

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