The Prophylactic Use of Topical Cyclosporine A 0.05% to Prevent Graft Versus Host Disease Related Dry Eye

Inclusion Criteria: * Male or female * At least 18 years of age * Approved candidate for allogeneic HSCT * Ability to understand and provide informed consent to participate in this study * Willingness to follow study instructions and likely to complete all required visits Exclusion Criteria: * History of ocular or eyelid surgery * History of glaucoma or ocular hypertension * History of herpetic eye disease * Patient with acne rosacea, blepharitis, or meibomitis, in the opinion of the investigator * Any ocular disorder or condition (including ocular infection, trauma, and disease) that could possibly interfere with the interpretation of the study results * Recent (3-month) history of wearing contact lens * Anticipated contact lens wear during any portion of the study * Recent (3-month) history of current use of topical steroids or antiglaucoma agents * Any punctal occlusion within 2 months of the screening visit * Significant sign or symptoms of dry eye (the definition of "dry eye" used for exclusion criteria is compatible with the recommendations of the NEI/Industry Workshop on Clinical Trials in Dry Eyes (Lemp, 1995) (see Appendix 1and 2)) * History of connective tissue disease or diabetes * Any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study