The purpose of this study is to determine the minimal number of patches needed to get an effective response. Patients enrolled in the study will be given 1, 2, 3 or 4 patches in a cycle by the order they enter the study. After the first 20 patients \[5 cycles\], the effect of the number of patches will be tested. If there is no distinct reduction of beta glucuronidase in the GCF or of gingival index at the tested sites, more patients will be enrolled. Patients will be added one cycle at a time with results being tested and analyzed. The enrollemnts of patients will stop when a dose response will be noticed or 15 cycles have been reached.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Patients enrolled in the study will be given 1, 2, 3 or 4 patches in a cycle by the order they enter the study.
Jerusalem Perio Center
Jerusalem, Israel
To determine the correct dosing of the herbal Patch [THPP]
Time frame: 3 months
To demonstarte the safety of THPP on the gingival tissue and in the oral cavity
Time frame: 3 months
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