The Effect of Rosuvastatin on Adenosine Metabolism

Radboud University Medical Center24 enrolled

Overview

The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Adenosine Metabolism

Interventions

placeboDRUG

1 dd for 7-10 days

rosuvastatinDRUG

1 dd 20 mg for 7-10 days

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 18 - 50 years * Signed informed consent Exclusion Criteria: * hypertension * hypercholesterolemia * diabetes Mellitus * alanine aminotransferase \> 90 U/L * creatinine Kinase \> 440 U/L * cardiovascular disease * GFR \< 80 ml/min

Locations (1)

Radboud University Nijmegen Medical Centre

Nijmegen, Netherlands

Outcomes

Primary Outcomes

forearm vasodilatory response to dipyridamole

Time frame: 7 days

Secondary Outcomes

lipid profile

Time frame: 7-10 days

Data from ClinicalTrials.gov

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