The purpose of this study is to see whether injecting local anaesthetic into the vaginal tissues,just prior to transvaginal egg collection,will decrease the amount of pain experienced by women having their eggs collected on an IVF cycle. All women will also receive intravenous sedation as required as well as a sleeping tablet thirty minutes prior to the procedure which is our routine procedure for egg collection.
Transvaginal oocyte retrieval is the most common method of oocyte collection in IVF cycles. A variety of different methods are used to provide analgesia/anesthesia for oocyte collection. Our unit has always used an oral pre-medication followed by intravenous fentanyl during the procedure but this doesn't seem to provide adequate analgesia for some women. The aim of this study was to compare the addition of intravaginal local anaesthetic injection versus saline placebo to our usual analgesia regime to see whether less intravenous fentanyl was required and whether the women experienced less pain during oocyte collection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
75
20 mls of 1% lignocaine solution for injection, 10mls into each side of upper vagina, under ultrasound guidance immediately prior to transvaginal oocyte retrieval under ultrasound guidance from each ovary
20mls of normal saline solution, 10mls injected each side into upper vagina under ultrasound guidance, immediately prior to ultrasound guided transvaginal oocyte retrieval from each ovary
The Fertility Centre
Christchurch, Canterbury, New Zealand
Total dose of iv fentanyl used during oocyte collection
Time frame: Length of oocyte collection (minutes)
Pain score (cm on a Visual Analogue Scale) at 6 different points during oocyte collection
Time frame: Actual point in time
Length of oocyte collection procedure
Time frame: Time taken (minutes)
Occurence of nausea or vomiting
Time frame: During oocyte collection procedure
Administration of atropine or anti -emetic
Time frame: During oocyte collection procedure
Time spent in recovery room
Time frame: Time from end of oocyte collection until discharge home
No of oocytes collected
Time frame: During oocyte collection procedure
Number of oocytes fertilised
Time frame: Assessed 18 hours after oocyte collection
Pregnancy outcome
Time frame: 7 weeks gestation
Number of embryos frozen
Time frame: Within 6 days of oocyte collection
Pulse rate at beginning and end of egg collection
Time frame: Point in time
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Maximum pulse rate during oocyte collection
Time frame: Point in time during oocyte collection procedure