CHIMES is a double blind, placebo controlled, randomized, multicenter study to test the hypothesis that NeuroAid is superior to placebo in reducing neurological deficit and improving functional outcome in patients with cerebral infarction of an intermediate range of severity.
Stroke is a major cause of death and disability. Previous clinical studies performed in China have shown that NeuroAiD increase stroke patients'recovery in terms of neurological disability and functional outcome{Chen et al,2009}and thus may be beneficial as part of a post-stroke rehabilitation programme. In the CHIMES study,we seek to test the hypothesis that NeuroAiD is superior to a placebo in reducing neurological deficit and improving functional outcome in patients recruited within 72 h after the ischemic stroke with intermediate range of severity {6\<\_NIHSS\<\_14}.More details of the study protocol have recently been published {Venketasubramanian et al,2009}.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
1,100
4 capsules 3 times daily, for three months
NeuroAid matched Placebo, 4 capsules 3 times daily, for three months
Prince of Wales Hospital
Hong Kong, Hong Kong
Distribution modified Rankin Scale grades for all randomized subjects
Time frame: 3 months
NIHSS, Barthel Index, MMSE
Time frame: 3 months
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