Dose Response and Efficacy of GW842166 in Pain

Inclusion Criteria: * Healthy male or female subjects aged 18 to 50 years inclusive * Body Weight \>50 Kg and BMI within the range 18.5 to 32 kg/m2 inclusive. * Women who are not of child bearing potential Exclusion Criteria: * The subject has a positive pre-study urine screen for drugs of abuse or positive alcohol test. * A positive pre-study (HIV), hepatitis B surface antigen or positive hepatitis C antibody result within 3 months of the start of the study. * Abuse of alcohol defined as an average weekly intake of greater than 28 units (21 units for women) or an average daily intake of greater than 3 units (2 units for women). 1 unit is equivalent to a half-pint (220 mL) of beer or 1 (25 mL) measure of spirits or 1 glass (125 mL) of wine. * Where participation in study would result in donation of blood in excess of 500 mL within a 56 day period.