Fructose Malabsorption in Northern Norway

University Hospital of North Norway182 enrolled

Overview

Different published studies has shown a possible co-variation between leakage of fructose to the great bowel and exacerbation of irritable bowel syndrome (IBS) symptoms. The aim of the FINN trial is to study the role of fructose malabsorption in patients with IBS in order to evaluate different diagnostic criteria for fructose malabsorption and at the same time study the effect of diet treatment in this cohort of patients and estimate the prevalence of fructose malabsorption.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

182

Conditions

Irritable Bowel Syndrome Fructose Malabsorption

Interventions

diet restrictionBEHAVIORAL

each meal should contain less than 2 gm fructose

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * IBS patients satisfying ROME 2 diagnostic criteria Exclusion Criteria: * Seriously ill * Organic abdominal disease * Other functional bowel disease

Locations (1)

Hospital of Rana Medical Dep. Helgelandsykehuset HF

Mo i Rana, Nordland, Norway

Outcomes

Primary Outcomes

VAS score og specific abdominal complaints.SGA score of relief related to abdominal complaints.

Time frame: 12 weeks

Secondary Outcomes

Estimate sensitivity,specificity,negative and positive predictive value using 50 gm fructose in breath test.Validate questionary for intolerance.Validate VAS in judging changes in abdominal complaint.Examine polymorphism i Glut5 transporter gene.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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