Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas

Inclusion Criteria: * Children age 0-6 months old. * Infants with infantile hemangiomas with complications that require systemic therapy to control their growth. To be eligible for enrollment infants must have clear indications for systemic treatment. * Clinical diagnosis of infantile hemangioma confirmed by tissue biopsy positive for GLUT-1 Immunohistochemical staining. If the risk of bleeding or permanent disfigurement from biopsy is believed to be too great then clinical and radiological characteristics may be used to establish the diagnosis after discussion with the study PI. Patients with GLUT-1 negative vascular tumors such as Kaposiform hemangioendothelioma, tufted angioma, and angiosarcoma are not eligible. * Hemangiomas must be greater than or equal to 50 cm2 clinically measured by taking the product of the two largest perpendicular diameters and have one of the following complications: ulceration, impairment of vision, impairment of hearing, obstruction of the airway, high output cardiac failure, bleeding, abdominal distention and/or compartment syndrome, compression of the spinal cord, or high risk of permanent disfigurement. * Adequate liver function defined as: * Total bilirubin ≤ 1.5 x upper limit of normal (ULN) for age, and * SGPT(serum glutamate pyruvate transaminase) (ALT) \< 2.5 x upper limit of normal (ULN) for age. * Patients who have received topical or intralesional corticosteroids are eligible to be enrolled. A washout of one week is required prior to study enrollment. Patients who have undergone surgical resection are eligible if they meet all inclusion criteria after surgery. * All patients' parents or legal guardians must sign a written informed consent. All institutional and FDA requirements for human studies must be met. Exclusion Criteria: * Children greater then 6 months old. * Contraindications to Vincristine: previously diagnosed neuropathy including sensory neuropathy type 1, Charcot- Marie-Tooth or childhood poliomyelitis. * Hemangioma involving the central nervous system (CNS) as Vincristine has poor CNS penetration. * Infants who have received prior systemic therapy with corticosteroids (oral or intravenous), interferon or Vincristine are not eligible for enrollment. * Patients receiving Vincristine who concomitantly require oral steroids for treatment of non-hemangioma indications such as asthma or atopic dermatitis will be removed from study. * A life-threatening intercurrent infection. * Infants with an underlying illness that would require use of general anesthesia (as opposed to sedation) for the MRI.