An Analysis of Peripheral Blood T Cell Subsets on Rheumatoid Arthritis

Inclusion Criteria: * Age 21 or above * Fulfilled the 1978 American college of Rheumatology(ACR) criteria for RA * Seropositive for RF with RF\>20 IU/ml * Active disease despite treatment with at least 2 stable dose of DMARDs for at least 16 weeks, including MRX\>10mg weekly * 4 or more swollen and/or tender joints * Stable dose of prednisolone\<=12.5mg/day or NASID for at lease 4 weeks * MTX\>10mg/wk and folic acid\>10 mg/wk for at lease 4 weeks Exclusion Criteria: * Little or no ability for self-care * Used a DMARD other than MTX(Leflunomide should be wash-out with cholestyramine 4 weeks prior screening) * Received intra-articular,intramuscular, or intravenous corticosteroids in the last 4 weeks * Concurrent treatment with any biologics within 8 weeks * Infected joint prosthesis during the previous 5 years * Autoimmune disease other than RA(except concurrent Sjogren's syndrome), active rheumatoid vasculitis, and history of systemic disease associated with arthritis, chronic fatigue syndrome. * Serious infections, such as hepatitis, pneumonia, pyelonephritis in the previous 3 months * Any chronic infectious disease such as renal infection, chest infection with bronchiectasis or sinusitis * Recurrent bacterial infections with encapsulated organisms, primary or secondary immunodeficiency * Active tuberculosis requiring treatment within the previous 3 years * Opportunistic infection such as herpes zoster within the previous 2 months * Any evidence of active cytomegalovirus;active Pneumocystis Jirovecl;or drug-resistant atypical mycobacterial infection * Known hypersensitivity to murine proteins * Current signs or symptoms of severe,progressive,or uncontrolled renal,hepatic,haematological,gastrointestinal,endocrine,pulmonary,cardias,neurological,or cerebral disease * A history of lymphoproliferative disease including lymphoma or signs suggestive of disease,such as lymphadenopathy of unusual size or location(ie,lymphadenopathy nodes,in the posterior tangle of the neck,infraclavicular epitrochlear,or periaortic areas);splenomegaly * Any know malignant disease except basal cell carcinoma currently or in the last 5 years