Patients with decompensated heart failure have high rates of mortality and morbidity despite recent improvements in diagnosis and treatment. Some aspects of their presentation such as renal failure, hyponatremia and congestive phenomena have received special attention, as they are associated with worse prognosis. The infusion of hypertonic saline solution has been tested in different conditions of cardiovascular collapse. Current evidence indicates that the infusion of hypertonic solution in heart failure patients can provide clinical and haemodynamic improvement. The investigators are testing the hypothesis that the infusion of hypertonic solution in association with diuretics may prevent the occurrence of renal dysfunction in patients with decompensated heart failure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
34
Patients in the intervention arm will receive 100ml of NaCl 7,5, twice daily during 3 days
Patients in the placebo arm will receive 100ml of NaCl 0,9% twice daily during 3 days
Heart Institute of São Paulo University Medical School
São Paulo, São Paulo, Brazil
Occurrence of renal disfunction
Time frame: During hospital admission
Improvement of hyponatremia
Time frame: During hospital admission
Improvement of congestive phenomena
Time frame: During hospital admission
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