Primary Anatomical Versus Primary Electrophysiological Approach in Circumferential Pulmonary Vein Ablation

University Hospital, Bonn200 enrolled

Overview

Randomized comparison between 2 techniques of circumferential pulmonary vein ablation in paroxysmal atrial fibrillation: Primary anatomical ablation with secondary closure of possible electrical gaps versus primary electrophysiological ablation at the sites of atrio-venous electrical breakthroughs with secondary circumferential ablation around the pulmonary vein orifice

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

200

Conditions

Paroxysmal Atrial Fibrillation

Interventions

primary electrophysiological approachPROCEDURE

primary ablation of atrio-venous breakthrough sites followed by circumferential ablation around pulmonary vein orifice

primary anatomical approachPROCEDURE

primary circumferential ablation around the pulmonary vein orifice followed by ablation of possible conduction gaps

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * paroxysmal atrial fibrillation * age over 18 years Exclusion Criteria: * persistent atrial fibrillation * reversible cause of atrial fibrillation * inability to comply with follow-up

Outcomes

Primary Outcomes

Freedom from atrial tachyarrhythmias at 6-months follow-up

Time frame: 6 months

Secondary Outcomes

Comparison of procedural characteristics (duration, fluoroscopy time, ablation time, ablation energy, complications)

Time frame: 6 months

Central Contacts

Lars M Lickfett, MD

CONTACT

*49-228-287-16670 lars.lickfett@ukb.uni-bonn.de

Data from ClinicalTrials.gov

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